Practice Quiz

MACE Medication Aide

Category - MACE

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Inflixamab is used as an anti-imflammtory agent in rheumatoid arthritis (RA) and IBDs such as ulcerative colitis (UC) and Crohn’s disease (CD). Which of the following should be monitored in a patient on inflixamab?

I. Opportunistic infections
II. WBC and Platelet counts
III. Signs and symptoms of hypersensitivity including fever, chills, rash, dyspnea, facial flushing, chest pain and severe headache
IV. Creatine phosphokinase levels
  1. I only
  2. II only
  3. I, II and III only
  4. IV only
Explanation
Answer: C - Infllixamab is a monoclonal antibody reacting with TNF-alpha. It is an anti-inflammatory but has immunosuppressive ahd hematopoietic effects as well. Hypersensitivity to the drug is relatively common and must be monitored. Creatine phosphokinase levels are more important in musculoskeletal disorders and generally do not need to be monitored in immunosuppressed patients.
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