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MACE Medication Aide

Category - MACE

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A patient arrives and asks you about his Depacon prescription. Which of the following is important to determine and why?

Whether the patient takes Clonazepam and has a history of absence seizure, because these may increase with Depacon.
Whether the patient drinks alcohol, because alcohol increases the CNS depressive effect blood concentration of valproate.
Both A and B are correct.
Neither A nor B are correct.

Explanation

Answer: C - Clonazepam, when taken with Depacon (valproate), does increase the risk of absence seizures in patients with a history of absence seizure. Also, alcohol use increases the depressive effects of Depacon. Any patient on Depacon requires monitoring for neurologic status.

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MACE Medication Aide

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MACE Medication Aide

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