MACE Medication Aide

Category - MACE

For which of the following life-threatening adverse effects is it MOST important to ensure that you have obtained informed consent? The patient has been prescribed lovastatin (Mevacor/Altocor).
  1. Asthenia
  2. Pruritis
  3. Rhabdomyolysis
  4. Lupus-like syndrome
Explanation
Answer: C - Rhabdomyolysis is the rapid breakdown of skeletal muscle fiber and is associated with statin use. Mortality can rise to 20% in some patients. Asthenia, a known adverse effect of lovastatin, indicates muscular weakness and may be important as an early indication of rhabdomyolysis but is not, of itself, life-threatening. Pruritis is itching and is non-life-threatening. All of the above have been reported for lovastatin. The other most common adverse effects of lovastatin are headache, blurry vision, flatulence, dyspepsia, myalgia, cramping, abdominal pain and photosensitivity. A lupus-like syndrome has not been reported for lovastatin.
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