Which of the following sets of drugs might slow the conduction through AV node and cause second degree heart block?
  1. Digoxin, statins, nitrates
  2. Procainamide, statins, fibrates
  3. Digoxin, beta-blockers, calcium channel blockers
  4. Calcium channel blockers, potassium channel openers
Explanation
Answer- C - Digoxin, beta-blockers, and calcium channel blockers might slow the conduction through AV node and cause second degree heart block. Pharmacologic agents that slow conduction through the atrioventricular node have been shown to cause second-degree atrioventricular block type I. These agents include cardioactive drugs such as digoxin, beta-blockers, calcium channel blockers, and certain antiarrhythmia drugs such as sodium channel blockers (procainamide).
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