NCLEX-RN

Answer: C - Histamine, which is highly concentrated in the mast cells, is released initially to promote vasodilation and vascular permeability. Bradykinins are the chemical mediators that cause pain in the injury. Some other kinins also attract neutrophils to that area. Leukocytes accumulate at the injured area to engulf microorganism and remove cellular debris. Fibrinogen, the last to arrive at the injury, helps in clot formation to isolate the injured area to prevent the spread of infection.