Answer: C - This patient presents with classic symptoms of peptic ulcer disease, a burning epigastric non-radiating pain that is worse at night and relieved by meals. In patients with symptoms of peptic ulcer disease, the gold standard for diagnosis is upper GI endoscopy to visualize the ulcer directly.
Endoscopy is more sensitive and specific than upper gastrointestinal barium studies. TTE and CT of the chest and abdomen with contrast are of little value in diagnosing peptic ulcer disease. Angiography would be appropriate in an upper GI bleed or mesenteric ischemia.