Radiographically, what bone disease appears as cotton wool due to decreased bone density?

  1. Town's syndrome
  2. Paget's disease of the bone
  3. Acromegaly
  4. Thyroid storm
Explanation

Answer: B - Radiographically, Paget's disease of the bone appears like cotton wool due to a decrease of bone density. The disease causes abnormal resorption and deposition of bone that result in distorted and dysfunction in bone remodeling. The disease is often polyostotic. Other signs and symptoms include bowing in the legs, increased head circumference with lion-like facial deformity, increased interdental spacing in the maxilla, and hypercementosis of the teeth. Treatment includes analgesics for bone pain, re-evaluations of prosthetics, and PTH antagonists to reduce bone turnover.

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