The mechanism by which intestinal mucosa are damaged in celiac sprue involves:
  1. Immunologic response to gliadin mediated by T lymphocytes
  2. The breakdown of gliadin into methionine and free fatty acids
  3. Binding of gliadin to receptor sites on the mucosal cell wall
  4. A & C
Explanation
Answer: D - The mechanism by which intestinal mucosa are damaged in celiac sprue involves an immunologic response to gliadin that is mediated by T lymphocytes, after gliadin binds to receptor sites on the mucosal cell wall. This reaction releases chemicals known as lymphokines which damage the cells. Gliadin does not contain either methionine or free fatty acids.
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