MACE Medication Aide

Answer: D - Methotrexate (MTX), Metronidazole (Flagyl) and Atorvastatin (Lipitor) are all Pregnancy category X medications; the use of contraception by women of reproductive age is required (FDA definition: “Adequate, well-controlled or observational studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities or risks. The use of the product is contraindicated in women who are or may become pregnant.”). Loratadine (Alavert, Claritin) is a histamine₁-receptor antagonist used for seasonal allergies and is a Pregnancy Category B (FDA definition: “Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.”).