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MACE Medication Aide

Category - MACE

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Which of the following may be used as an antidote to benzodiazepine overdose?

I. Nalmefene
II. Physostigmine
III. Protamine
IV. Flumazenil

I only
II only
I, II and III only
IV only

Explanation

Answer: D - Flumazenil is used as an antidote to benzodiazepines and acts as a competitive inhibitor at the GABA receptors. Nalmefene is a competitive antagonist at opioid receptors and is used in alcoholism treatment. Physostigmine is a classic acetylcholinesterase inhibitor and is used as an antidote for anticholinergics. Protamine is an anti-coagulant and complexes with heparin and neutralizes the anti-coagulative properties of both agents.

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MACE Medication Aide

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