Which of the following drugs may be considered hepatotoxic?
I. Isoniazid, ceftizoxime, phenytoin
II. Anakinra, captopril, escitalopram, esmolol
III. Dobutamine, tamoxifen, temozolomide
IV. Cefoxitin, acetaminophen, delavirdine
Explanation
Answer: D − Cefoxitin is a 2nd generation cephalosporin, acetaminophen is an NSAID, delavirdine is a NNRTI (non-nucleoside reverse transcriptase inhibitor), and are all associated with hepatotoxicity. Isoniazid is an antitubercular, ceftizoxime is a 3rd generation cephalosporin, and phenytoin is an anticonvulsant. All are associated with hepatotoxicity. The drugs listed in choices II and III are not associated with hepatotoxicity. Anakinra is an Interleukin-1 blocker. Captopril is an ACE inhibitor. Escitalopram is an SSRI. Esmolol is a cardioselective beta blocker. Dobutamine is a sympathomimetic. Tamoxifen is a SERM (Selective Estrogen Receptor Modulator).Temozolomide is an alkylating agent.
