Podiatry and Medical - Set 1

Category - Podiatry Part I

Which of the following beta-lactam drugs has good activity against beta-lactamase-producing organisms and penetrates readily into cerebrospinal fluid?
  1. Amoxicillin
  2. Cefazolin
  3. Clavulanic acid
  4. Imipenem
Explanation
Answer − D − Imipenem is the only drug listed that is effective against many beta-lactamase-producing organisms and penetrate the blood-brain barrier of the cerebrospinal fluid. Imipenem is a beta lactam that has a broad spectrum of use against anaerobic and aerobic bacteria, particularly Pseudomonas aeruginosa and Enterococcus species.
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