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Podiatry and Medical - Set 1

Category - Podiatry Part I

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Which of the following antiviral agents uses viral thymidine kinase as part of its activation pathway?

Acyclovir
Amantadine
Foscarnet
Saquinavir

Explanation

Answer − A − Acyclovir is an acyclic guanine nucleoside analog that undergoes activation by phosphorylation by herpesvirus thymidine kinase (but not the host thymidine kinase). This activation forms the acyclovir triphosphate structure and causes DNA chain termination.

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