MACE Medication Aide

Category - MACE

Which of the following are possible signs/symptoms/complications of tretinoin (Retin-A)?

I. GI hemorrhage.
II. Cerebrovascular accident
III. Disseminated intravascular coagulation (DIC)
  1. All of the above
  2. None of the above
  3. I only
  4. I and III only
Explanation
Answer: A - All the complications listed are possible with tretinoin use. Other adverse effects include multiple organ failure, hepatosplenomegaly, MIs and renal failure. Tretinoin is an antineoplastic dermatologic agent used to treat acute promyelocytic leukemias, acne vulgaris and for cosmetic purposes.
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