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NAPLEX Pharmacy Exam Prep

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What is the mechanism of action of gentamicin?
  1. It is an aminoglycoside and is bacteriocidal against Gram (-) bacteria by irreversibly binding the 30S subunit of bacterial ribosomes.
  2. It is a 4th generation cephalosporin and has broad activity against both Gram (+) and Gram (-) bacteria. It blocks cell wall synthesis and cell division.
  3. It is a monobactam, killing Gram (-) bacteria by binding to penicillin-binding protein 3.
  4. It is an aminoglycoside and is bacteriocidal against Gram (-) bacteria by irreversibly binding the 50S subunit of bacterial ribosomes
Explanation
Answer - A - Gentamicin is an aminoglycoside and is bacteriocidal against Gram (-) bacteria by irreversibly binding the 30S subunit of bacterial ribosomes and NOT the 50S subunit. The mechanism of action described for 4th generation cephalosporins and monobactams is correct.
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