COMLEX Osteopathic Medicine

Category - Digestion

Pepsinogen is an enzyme that, when released into the stomach, is activated by acid to form Pepsin. Pepsin is responsible for the hydrolysis of which substance?
  1. Carbohydrates
  2. Proteins
  3. Lipids
  4. All of the above
Explanation
Answer - B - Pepsin is responsible for the hydrolysis or break-down of proteins in the stomach into polypeptides and partially-digested proteinaceous foods. 99% of the pepsinogen that is released into the stomach stays there to activate pepsin. The remaining 1% gets absorbed and goes into the blood stream.
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