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MACE Medication Aide

Category - MACE

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Leucovorin can be given as a “rescue therapy” for which of the following?

Doxorubicin
Methotrexate
Cytarabine
None of the above

Explanation

Answer: B - Leucovorin allows DNA replication to continue in healthy cells by providing an alternative folic acid source independent of dihydrofolate reductase. Since methotrexate is a dihydrofolate reductase inhibitor, leukovorin can provide a “rescue.” Doxorubicin is an intercalating agent, and cytarabine is an inhibitor or DNA polymerase. There is no overlap in the mechanisms, and leucovorin would not rescue any of those two treatments.

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MACE Medication Aide

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MACE Medication Aide

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