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FPGEE Foreign Pharmacy

Category - Pharmaceutical

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Drugs can either induce or inhibit various metabolic enzymes and thereby affect dosing and serum concentrations. Which of the following drugs is known to inhibit metabolic enzymes as opposed to inducing activity?

Erythromycin
Carbamazepine
Rifampin
St John’s Wort

Explanation

Answer: A - Erythromycin inhibits the CYP34A pathway. The other agents listed are inducers of activity. Carbamazepine is an auto-inducer (it stimulates its own metabolism). Rifampin and St Johns wort induce CYP34A activity.

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FPGEE Foreign Pharmacy

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