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MACE Medication Aide

Category - MACE

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A patient is taking 40 mg PO of lovastatin with his evening meal. He comes to you saying that for the last 2-3 weeks, he feels as if his legs are cramping. Which of the following tests would you recommended?

A CBC (complete blood count) and a full comp metabolic (chemistries) test
Lipid levels including VLDL levels
Total lovastatin serum concentrations
Creatine phosphokinase (CPK), the MM isoenzyme

Explanation

Answer: D - A patient on a statin complaining of muscle cramping should have his liver function tested and CPK-MM tested for evidence of muscle damage. One of the serious adverse effects of a statin is rhabdomyolysis, and the patient’s cramping may be symptomatic. CPK-MM levels are a good indicator of skeletal muscle damage occurring during rhabdomyolysis.

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MACE Medication Aide

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MACE Medication Aide

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