Practice Quiz

MACE Medication Aide

Category - MACE

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A patient has a glucose-6-phosphate dehydrogenase (G6PD) deficiency. Of the following drugs, which should be avoided in this patient?

I. Quinolones
II. NSAIDs
III. Food colorings
IV. Vitamin B12
  1. I only
  2. II only
  3. I, II and III only
  4. All should be avoided
Explanation
Answer: C - Quinolones, NSAIDs and various food colorings should be avoided in patients with G6PD deficiency. The enzyme is found in red blood cells and protects against oxidative stress. G6PD has over 400 polymorphic variants. African Americans have some of the highest rates of polymorphism. This is believed to have developed as an evolutionary adaptation to malarial infection. There is no need to avoid Vitamin B12.
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