A patient diagnosed with a peptic ulcer is prescribed with sucralfate. Which of the following instructions should be given to the patient to ensure that the medication is taken appropriately?
  1. Sucralfate is taken with meals
  2. Sucralfate should be administered together with an antacid
  3. Sucralfate should be administered two hours apart from warfarin sodium
  4. Sucralfate can cause diarrhea; increased fiber intake is recommended
Explanation
Answer - C - Sucralfate may impede the absorption of warfarin sodium, phenytoin, theophylline, and digoxin. These medications should be administered at least two hours apart from each other. Sucralfate should be administered on an empty stomach and at least 60 minutes apart from an antacid. Constipation is a common side effect of sucralfate.
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