ANCC Medical-Surgical Nursing Exam Prep

Category - Medical-Surgical Nursing Practice Test

The serum levels of which of the following drugs are not decreased by phenytoin?
  1. Doxycycline
  2. Amiodarone
  3. Cyclosporine
  4. Furosemide
  5. Quinidine
Explanation
Answer: B - Phenytoin is metabolized primarily by hepatic microsomal enzymes. Concomitant use of drugs that inhibit or enhance hepatic microsomal activity results in altered drug metabolism/activity level. Of the drugs choices listed above, phenytoin increases the serum levels of just amiodarone; serum levels of amiodarone are not decreased by phenytoin.

For the remaining drugs, doxycycline, cyclosporine, furosemide, and quinidine, phenytoin decreases serum levels.
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