Podiatry and Medical - Set 2

Category - Podiatry Part II

Which of the following statements best defines the cause of myasthenia gravis?
  1. Acetylcholine synthesis in motor neurons is impaired
  2. Acetylcholinesterase synthesis is inhibited
  3. Autoantibodies destroy cholinergic receptors at the postsynaptic membrane, preventing binding of acetylcholine
  4. Neurotransmitter release is impaired at the presynaptic membrane of the neuromuscular junction
Explanation
Answer − C − The statement that best defines the cause of myasthenia gravis is autoantibodies that destroy cholinergic receptors at the postsynaptic membrane, preventing binding of acetylcholine. Myasthenia gravis is an autoimmune disorder where autoantibodies target the postsynaptic cholinergic receptors and destroy them.
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