Which of the following is not a correct match between the anticoagulant and its mechanism of action?
  1. Heparin - inhibits the conversion of prothrombin to thrombin
  2. Warfarin - interferes with formation of vitamin K dependent clotting factors in the liver
  3. Lepirudin - directly inhibits thrombin formation
  4. Low molecular weight heparins - prevents conversion of fibrinogen to fibrin
Explanation
Answer- D - “Low molecular weight heparins - prevents conversion of fibrinogen to fibrin” is not a correct match. Heparin is a protein that inhibits the conversion of prothrombin to thrombin, which prevents fibrinogen being converted to fibrin. Lepirudin directly inhibits thrombin formation, while low molecular weight heparins block factors Xa and IIa, which inhibit thrombus and clot formation. Warfarin prevents clot formation by interfering with formation of vitamin K dependent clotting factors in the liver.
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