MACE Medication Assistant Exam Prep

Category - Pharmacological

Which of the following drugs is the treatment of choice for Candida albicans infection?
  1. Fluconazole
  2. Tolnaftate
  3. Griseofulvin
  4. Amphotericin B
  5. Calcium Citrate
Explanation

Answer − A− The drug that is the treatment of choice for Candida albicans infection is fluconazole. Fluconazole is an antifungal that works by preventing the fungal enzyme Cytochrome P450 from working. In addition, itraconazole is also considered a drug of choice for systemic Candida albicans infection.

Fluconazole is an antifungal medication that is used to treat infections caused by the yeast Candida. It works by disrupting the formation of the fungal cell wall, which is essential for the survival of Candida. The drug binds to a specific protein in the cell wall called ergosterol, a component of the fungal cell membrane. By binding to ergosterol, fluconazole interferes with the normal function of the cell wall, leading to the death of the Candida cells.

In addition to its direct effects on Candida cells, fluconazole can also affect other components of the fungal cell, such as enzymes and transporters, which are involved in the growth and survival of the yeast. By inhibiting these cellular functions, fluconazole helps to stop the spread of Candida and reduce the overall population of the yeast, leading to the resolution of the infection.

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