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Podiatry and Medical - Set 1

Category - Podiatry Part I

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Which of the following agents produces vasodilation by increasing nitric oxide synthesis in endothelial cells?

Diazoxide
Histamine
Minoxidil
Nitroprusside

Explanation

Answer − B − Histamine activates nitric oxide synthase by binding to H1 receptors in the endothelium. Nitric oxide synthesis is increased and this molecule rapidly diffuses into the adjoining smooth muscle, where it causes vasodilation.

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