AP World History

Answer - C - Nations that were very dependent upon global trade were most affected by the Great Depression.

Key Takeaway: A great decline in international business occurred in the late 1920s, largely due to immense trade competition between nations. In response, many nations, such as the United States, established strict barriers and trade limits in the form of tariffs in order to protect their domestic manufacturers. Because of this, nations that were highly dependent upon global trade suffered greatly in the Great Depression.