Correct Response: A. The rough endoplasmic reticulum is the portion of the endoplasmic reticulum to which ribosomes are attached. Together, the endoplasmic reticulum and the ribosomes produce membrane proteins and proteins that are to be secreted from the cell. Additionally, carbohydrate chains are frequently attached to proteins in the rough endoplasmic reticulum to produce glycoproteins. For these reasons, the rough endoplasmic reticulum is well developed in cells that produce large quantities of secreted and/or glycoproteins. The detoxification of drugs or poisons (B) occurs in the smooth endoplasmic reticulum. The movement of charged particles (ions) across the cell membrane is called chemiosmosis (C), and the rough endoplasmic reticulum does not have a direct role in this. The hydrolysis of macromolecules (D) frequently occurs in lysosomes and by proteasomes in the cytoplasm.
