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FPGEE Foreign Pharmacy

Category - Pharmaceutical

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Drugs undergo various metabolic processes that affect the solubility of the drug. Which of the following enzymatic reactions would most likely result in the least change in water solubility?

Glucuronidation
Hydroxylation
Sulphonation
Cyclization

Explanation

Answer: B - Hydroxylation results in the addition of a hydroxyl (-OH) group and generally has little effect on drug solubility. Glucuronidation, the addition of highly water soluble glucuronic acid, increases water solubility significantly. Sulphonation also increases water solubility, whereas cyclization decreases water solubility.

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FPGEE Foreign Pharmacy

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