Practice Quiz

FPGEE Foreign Pharmacy

Category - Pharmaceutical

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A comparison is made for the bioavailability of a particular drug. It is given as a single oral dose and as a single iv dose. When comparing the AUC (Area under Curve) for each of these delivery systems, which of the following results is possible?

I. AUC(iv) < AUC(po)
II. AUC(iv) > AUC(po)
III. AUC(iv) = AUC(po)
  1. Not enough information is given to determine which result is possible.
  2. I only
  3. II only
  4. II or III only
Explanation
Answer: D - The AUC is a measurement of the bioavailability of a drug. A drug administered intravenously has - by definition - an AUC=1. This is a maximum value. Oral preparations may have equal to or less than the same AUC as an intravenously delivered drug, but they can never have a greater AUC.
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