NCLEX-RN

Category - Pharmacological

A client with bladder cancer is receiving cisplatin (Platinol). The nurse should expect the administration of which of the following drugs to prevent renal toxicity?
  1. Ifosfamide (Ifex)
  2. Leucovorin (folinic acid)
  3. Dexrazoxane (Zinecard)
  4. Amifostine (Ethyol)
Explanation
Answer: D - Cisplatin can cause a severe form of kidney disease. Amifostine is administered before cisplatin to reduce its nephrotoxic effects. Amifostine’s thiol metabolite detoxifies the cytotoxic platinum-containing metabolites of cisplatin.
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