Dr. Santos prescribes oral rifampin (Rimactane) and isoniazid (INH) for a client with a positive Tuberculin skin test. When informing the client of this decision, the nurse knows that the purpose of this choice of treatment is to:
  1. Cause less irritation to the gastrointestinal tract
  2. Destroy resistant organisms and promote proper blood levels of the drugs
  3. Gain a more rapid systemic effect
  4. Delay resistance and increase the tuberculostatic effect
Explanation
Answer - D - Delay resistance and increase the tuberculostatic effect. Pulmonary TB is treated primarily with chemotherapeutic agents for 6-12 months. Prolonged treatment duration is necessary to ensure eradication of the organisms and to prevent relapse. The increasing prevalence of drug resistance points to the need to begin the treatment with drugs in combination. Using drugs in combination can delay the drug resistance.
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