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Podiatry and Medical - Set 1

Category - Podiatry Part I

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Which one of the following drugs inhibits bacterial protein synthesis, preventing the translocation step via its intersection with the 50s ribosomal subunit?

Clindamycin
Gentamicin
Chloramphenicol
Imipenem

Explanation

Answer − A − The drug that inhibits bacterial protein synthesis, preventing the translocation step via its interaction with the 50s ribosomal subunit, is clindamycin. Clindamycin has a mechanism of action similar to, if not identical with, erythromycin and related macrolides. They bind to rRNA bases on the 50s subunit to prevent translocation of peptidyl-mRNA from the acceptor to the donor site.

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Podiatry and Medical - Set 1

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Podiatry and Medical - Set 1

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