Practice Quiz

FPGEE Foreign Pharmacy

Category - Clinical

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Which of the following, when used in combination, is likely to carry the risk of inducing serotonin syndrome?
  1. Escitalopram and hydralazine
  2. Orlistat and atenolol
  3. Albuterol and alendronate.
  4. Any of the above could induce serotonin syndrome.
Explanation
Answer: A − Escitalopram is an SSRI (Selective Serotonin Reuptake Inhibitor) and hydralazine is a non-selective MAOI and a vasodilator. Venlafaxine and hydralazine in combination could theoretically increase levels of serotonin, resulting in Serotonin Syndrome. Orlistat is a GI lipase inhibitor. Atenolol is an adrenergic antagonist. Albuterol is a bronchodilator. Alendronate is a bisphosphonate. None of the drugs listed besides venlafaxine and hydralazine are likely to affect serotonin pathways.
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