FPGEE Foreign Pharmacy

Category - Clinical

Which of the following life-threatening adverse effects is most important to discuss with a patient who is prescribed lovastatin (Mevacor/Altocor)?
  1. Asthenia
  2. Pruritus
  3. Rhabdomyolysis
  4. Flatulence
Explanation
Answer: C - Rhabdomyolysis is the rapid breakdown of skeletal muscle fiber and is associated with statin use. Mortality can rise to 20% in some patients. Asthenia indicates muscular weakness and may be important as an early indication of rhabdomyolysis, but is not of itself life threatening. Pruritus is itching and is non-life threatening. Flatulence is an increase in bowel gases; unpleasant, but non-life-threatening.
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