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Podiatry and Medical - Set 1

Category - Podiatry Part I

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Which of the following effects is the most important adverse reaction of spironolactone therapy?

Anti-androgen
Cardiac arrhythmia
Dehydration
Hyperkalemia

Explanation

Answer − A − The effect that is the most important adverse reaction of spironolactone therapy is anti-androgen. Spironolactone acts as an anti-androgen by decreasing the production of testosterone by the adrenal gland and by preventing DHT (dihydrotestosterone) from binding to its androgen receptor.

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