What syndrome displays freckle-like spots on the hands, oral mucosa, and perioral skin?
                            
                         
                        
                            
                        
                             
                            
                            
                            
                                Explanation
                            
                                
                                    Answer: D - Peutz-Jeghers syndrome displays freckle-like spots on the hands, oral mucosa, and perioral skin.  The freckle-like spots are not considered cancerous, but there is an association with intestinal polyposis, GI adenomas, ovarian, pancreatic, and breast carcinoma.  The spots are usually small blue-gray macules in the vermillion zone, buccal mucosa, tongue, mouth, nose, anus, genital areas, and vermillion zone.