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PANCE Practice Test

Category - PA

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What class of drugs is recommended as the first line therapy for hypercholesterolemia, after lifestyle modifications?

HMG CoA reductase inhibitors (statins)
Calcium channel blockers
Beta channel antagonists
Antithrombolytics

Explanation

Answer: A - The statins work by blocking an enzyme, HMG-CoA reductase that is the rate-limiting step in the manufacture of cholesterol. Statins reduce LDL-cholesterol, total cholesterol, and triglycerides and slightly increase high-density lipoprotein (HDL-c).

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