ADA NBDE National Board Dental Part I

Answer: A - The primary positive control of hepatic gluconeogenesis is exerted by high acetylcoenzyme A (acetyl-CoA) levels. The first step in gluconeogenesis is the formation of oxaloacetate from pyruvate. The enzyme controlling this step is pyruvate carboxylase, an allosteric enzyme that does not function in the absence of its primary effector acetyl-CoA or closely related acyl-CoA.