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FPGEE Foreign Pharmacy

Category - Clinical

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Patients taking protease inhibitors should avoid drinking large amounts of grapefruit juice because it ____________ CYP_____________ and ____________ blood levels of the drug.

Inhibits, 3A4, increases
Induces, 3A4, increases
Inhibits, 2D6, increases
Induces 2D6, increases

Explanation

Answer: A − Ingesting large amounts of grapefruit juice inhibits the enzyme CYP3A4. CYP3A4 is involved in the metabolism of protease inhibitors-thus, grapefruit juice would increase the serum levels of the drug.

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FPGEE Foreign Pharmacy

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FPGEE Foreign Pharmacy

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