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FPGEE Foreign Pharmacy

Category - Clinical

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In which of the following treatments could leucovorin be given as a rescue therapy?

Methotrexate
Doxorubicin
Cytarabine
None of the above.

Explanation

Answer: A − Leucovorin allows for continued DNA replication in healthy cells by providing an alternative folic acid source independent of dihydrofolate reductase. Since methotrexate is a dihydrofolate reductase inhibitor, leucovorin can provide a “rescue.” Doxorubicin is an intercalating agent, while cytarabine is an inhibitor or DNA polymerase. Since there is no overlap in the mechanisms, leucovorin would not rescue any of those two treatments.

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