If your patient is on Clonazepam, what is important to determine and why?

  1. Whether the patient takes Clonazepam and has a history of absence seizure, because these may increase with Depacon.
  2. Whether the patient drinks alcohol, because alcohol increases the CNS depressive effect blood concentration of valproate.
  3. Both A and B are correct.
  4. Neither A nor B are correct.
Explanation
Answer: C - Clonazepam, when taken with Depacon (valproate), does increase the risk of absence seizures in patients with a history of absence seizure. Also, alcohol use increases the depressive effects of Depacon. Any patient on Depacon requires monitoring for neurologic status.
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