Veterinary Technician

Category - Pharmacology

If a medication is administered to an unhealthy patient whose drug clearance ability is reduced by 50%, what effect will this have on the half-life of the drug?
  1. The half-life will decrease by half.
  2. The half-life will remain the same.
  3. The half-life will double.
  4. It will decrease the amount of drug circulating in the blood plasma by 50%.
Explanation
Answer: C - The half-life will double if a drug is administered to a patient whose clearance capability is reduced by 50%. When a patient's clearance capability is reduced, elimination of the drug is slowed, thereby increasing the half-life.
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