Podiatry and Medical - Set 1

Category - Podiatry Part I

If a drug is highly bound to plasma proteins, it:
  1. Has a large volume of distribution
  2. Has a high renal clearance
  3. Is a likely candidate for drug interactions
  4. Is most likely carried by alpha-glycoprotein
Explanation
Answer − C − If a drug is highly bound to plasma proteins, it is a likely candidate for drug interactions. Competition between drugs for plasma protein binding sites can lead to drug interactions (e.g., the displacement of warfarin by sulfonamides may increase its anticoagulant effects).
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