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FPGEE Foreign Pharmacy

Category - Clinical

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A patient is taking 40 mg PO of lovastatin with his evening meal. He comes to you saying that for the last 2-3 weeks, his legs feel like they are cramping. Which of the following tests would be recommended?

A CBC (complete blood count) and a full Comprehensive Metabolic Panel (chemistries)
Lipid levels including VLDL levels
Total lovastatin serum concentrations
Creatine phosphokinase (CPK), the MM isoenzyme

Explanation

Answer: D − A patient on a statin complaining of muscle cramping should have his liver function tested and CPK-MM tested for evidence of muscle damage. One of the serious adverse effects of a statin is rhabdomyolysis and the patient’s cramping may be symptomatic. CPK-MM levels are a good indicator of skeletal muscle damage occurring during rhabdomyolysis.

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FPGEE Foreign Pharmacy

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