Practice Quiz

FPGEE Foreign Pharmacy

Category - Pharmaceutical

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A patient has a Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency. Of the following drugs, which should be avoided in this patient?
  1. Quinolones
  2. Macrolides
  3. Omeprazole
  4. Vitamin B12
Explanation
Answer: A - Quinolones should be avoided in patients with G6PD deficiency. The enzyme is found in red blood cells and protects against oxidative stress. G6PD has over 400 polymorphic variants. African Americans have some of the highest rates of polymorphism. This is believed to have been developed as an evolutionary adaptation to malarial infection. There is no need to avoid the other medications in patients with G6PD deficiencies.
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