A patient at your practice has been diagnosed with Blastomycosis and is receiving multiple IV doses of Amphotericin B. What would be a major concern regarding side effects in this patient?
  1. Nephrotoxicity
  2. Neurotoxicity
  3. Neoplasia
  4. All of the above
Explanation
Answer: A - Nephrotoxicity would be a major concern regarding side effects in a patient receiving Amphotericin B. Within 15 min of IV administration, renal arterial vasoconstriction occurs and lasts for 4-6 hours. This causes diminished renal blood flow and glomerular filtration.
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