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PCAT Review Questions - Pharmacy College

Category - Biology

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A mutation in DNA that changes the DNA sequence but does not alter the amino acid of a protein is known as ____________.
  1. Silent mutation
  2. Frameshift mutation
  3. Insertion mutation
  4. Deletion mutation
  5. Point mutation
Explanation
Answer: A, silent mutation. A silent mutation in DNA does not change the amino acid sequence of a corresponding protein.

Key Takeaway: In silent mutations, the DNA sequence is altered, but the resulting protein is not. This is the result of a level of redundancy in the mRNA code. Most amino acids can be coded by more than one codon, so a change in DNA does not always lead to a change in protein sequence.
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