NCLEX-RN

Category - Reduction of Risk

A client with pulmonary tuberculosis is prescribed with the front-line drugs for pulmonary tuberculosis, which include ethambutol, pyrazinamide, rifampicin, and isoniazid. Which of these drugs will significantly affect the liver function test?
  1. Rifampicin
  2. Ethambutol
  3. Pyrazinamide
  4. Isoniazid
Explanation
Answer: C - Pyrazinamide can cause severe liver damage resulting in an increased bilirubin level, altered liver enzymes, increased alkaline phosphatase, and increased serum transaminase levels. Rifampicin use is associated with shock-like syndrome. Ethambutol results in visual disturbances while isoniazid would most likely cause nerve damage.
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