NCLEX-RN

Category - Pharmacological

A client is receiving a high dose of methotrexate (Folex). Leucovorin (citrovorum factor) is also prescribed. The nurse understands that the addition of leucovorin is for which of the following actions?
  1. To excrete uric acid
  2. To save normal cells
  3. To encourage nucleic acid synthesis
  4. To stop skin scales from forming
Explanation
Answer: C - Methotrexate is used to treat cancers of the breast, skin and lungs by interfering with the metabolism of cancer cells. Methotrexate is severely damaging to the liver, lungs, bone marrow and kidneys and can cause life-threatening side-effects. Leucovorin is given to rescue the normal cells from methotrexate by a process called the leucovorin rescue. This drug, an active form of folate, helps in the synthesis of red and white blood cells and hemoglobin.
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